Read firstPractice-changingEvidence update
Association between the time to norepinephrine initiation and mortality in patients with sepsis
EMJ20 Aug 2026Sepsis
Clinical takeaway
Avoid preventable delay when norepinephrine is indicated, but treat the 60-minute threshold as observational evidence rather than proof that earlier treatment itself reduces mortality.
EDCritix summary
In a prospective multicentre cohort of 138 patients with sepsis, non-survivors started norepinephrine later than survivors; initiation within 60 minutes of hypotension was associated with lower 28-day mortality.