BackgroundBackgroundEvidence update

Is intranasal adrenaline effective for the treatment of anaphylaxis?

EMJ29 Aug 2026Reviews

Continue intramuscular adrenaline as first-line treatment for anaphylaxis. Current evidence is insufficient to substitute the intranasal route.

EDCritix summary

This shortcut review found only eight directly relevant clinical reports comparing intranasal with intramuscular adrenaline for anaphylaxis, mostly weak case-series evidence; it could not establish equivalent effectiveness.