High-yieldHigh-yieldEvidence update
In reply:
Annals of Emergency Medicine1 Sept 2026Trials
Clinical takeaway
Treat sphenopalatine ganglion block as an optional adjunct for selected headache patients, not a proven replacement for standard therapy. Discuss the uncertain response and lack of a clearly superior technique.
EDCritix summary
The trial authors acknowledge methodological limitations and that their study did not identify one optimal sphenopalatine ganglion block technique. They report that a subset of ED headache patients achieved rapid relief without systemic medication and that clinicians could perform the block with minimal training.