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Interpreting a Dose-Finding Trial of Sphenopalatine Ganglion Block for Acute Headache
Annals of Emergency Medicine1 Sept 2026Trials
Clinical takeaway
Do not interpret the absence of a dose-response as proof of no treatment effect; read the trial and correspondence together before drawing procedural or dosing conclusions.
EDCritix summary
This letter highlights methodological limitations that may complicate interpretation of a negative dose-response trial of bupivacaine sphenopalatine ganglion block for ED headache.