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Prehospital epinephrine as a bridge to survival in traumatic cardiac arrest: A nationwide propensity score-matched analysis

AJEM29 Jun 2026Trauma

Given the observed association with increased survival and ROSC rates, continuing current protocols recommending prehospital epinephrine in traumatic arrest seems supported. However, remember that this data does not solidify a benefit regarding neurological outcomes, so don't change your approach based solely on this for prognostication. Further studies are needed to refine timing and patient selection.

EDCritix summary

This nationwide propensity score-matched analysis examined whether administering epinephrine in the prehospital setting improves outcomes following traumatic cardiac arrest. The authors analyzed registry data and concluded that giving epinephrine before reaching the hospital was associated with both increased survival to discharge and higher rates of return of spontaneous circulation (ROSC) while still out of the ambulance. While these findings suggest a benefit, the paper cautions that the link between prehospital epinephrine use and favorable neurological outcomes is not clear, emphasizing the need for more research to pinpoint optimal timing and patient selection criteria.