BackgroundBackgroundClinical trial
Sickle Cell Acute Pain Episodes: Lessons Learned from the Prematurely Halted PECARN STArT Trial
ALiEM24 Aug 2026Trials
Clinical takeaway
PECARN's phase 3 STArT trial of intravenous arginine for sickle cell acute pain episodes was halted early for futility. The lesson is in the 61-hour spread in time to crisis resolution between children's hospitals, and in what the trial actually enrolled.
EDCritix summary
PECARN's phase 3 STArT trial of intravenous arginine for sickle cell acute pain episodes was halted early for futility. The lesson is in the 61-hour spread in time to crisis resolution between children's hospitals, and in what the trial actually enrolled. The post Sickle Cell Acute Pain Episodes: Lessons Learned from the Prematurely Halted PECARN STArT Trial appeared first on ALiEM .